Do you have any trouble talking to people with intellectualdisabilities?
你和有智力缺陷的人交谈有困难吗?

探究 have trouble (in) doing sth意为“做某事有困难”。表示“在某方面有困难”时,用短语“have trouble with sth”，此处trouble相当于difficulty.
l have trouble (in) communicating with my parents.我与父母交流有困难。

拓展 trouble前面可用no, much, some, a little,little等修饰。l have some trouble (in) working out the problem.
我在解这道题的时候有点费劲。
He has no trouble with English.他学英语毫不费劲。